#1: Mini Symposium: Vulnerable Plaque Biomechanics and Clinical Applications
Co-Chairs: Professor Dalin Tang, Worcester Polytechnic Institute, USA Dr. Liang Wang, Southeast University, China
Summary: This symposium aims to bring together experts across the range of engineering science disciplines to discuss the state-of-the-art in development of vulnerable plaque biomechanics and its clinical application. Atherosclerotic plaque development and rupture are closely associated the plaque mechanical conditions, including hemodynamics and structural mechanics. These mechanical conditions have the potential to improve the assessment the vulnerable plaque and forecasting adverse major cardiovascular events with integration of plaque morphology from multiple non-invasive or invasive imaging technologies. The symposium will highlight the experimental and computational techniques in the vulnerable plaque biomechanical research, and the influence of biomechanics in clinical patient-screening, diagnosis and intervention for atherosclerosis-related cardiovascular diseases.
Topics will include but not be limited to: • Computational simulation for plaque biomechanics • Experimental investigation for plaque material properties and biomechanics • Clinical Application for plaque biomechanics
#2: Mini Symposium:Ventricle Modeling, Biomechanics and Clinical Application
Co-Chairs: Professor Dalin Tang, Worcester Polytechnic Institute, USA
Professor Xueying Huang, Xiamen University, China
Summary: This symposium aims to bring experts together and provide a platform for exchange of ideas and disseminate the recent developments in Ventricle Modeling, Biomechanics and Clinical Application. The symposium will highlight challenges spanning from heart modeling (including ventricles and valve modeling) to dissect the mechanisms for cardiac dysfunction, cardiac hemodynamics, and cardiac valves. Computational, analytical challenges and clinical applications will be a special focus.
Topics will include but not be limited to: • Computational modeling for ventricles • Multi-scale of heart function • Modeling of heart valves • Cardiac tissue mechanics • Ventricular hemodynamics
• Biomechanical Heart Modeling for Clinical Applications
#3: Mini Symposium: FRET and Bio-imaging Study in Advancing Biomechanics
Co-Chairs: Professor Mingxing Ouyang, Changzhou University, China
Professor Yingxiao Peter Wang, University of California, San Diego, USA
Summary: Imaging has been a powerful tool to visualize biomechanical activities at multi-scale levels. FRET (fluorescence resonance energy transfer) technology provides an approach with spatiotemporal resolution in advancing our understanding of biomechanics in live cells. This symposium focuses on the recent progresses in biomechanics & biophysics by utilizing FRET and bio-imaging tools.
#4: Mini Symposium: Inverse Problems in Soft Tissue Biomechanics and Mechanobiology
Co-Chairs: Professor Yue Mei, Dalian University of Technology, China Professor Stéphane Avril, Mines Saint-Etienne, France Professor Jia Lu, University of Iowa, USA
Summary: It has become a common practice to combine image based full-field displacement measurements experienced by tissue samples in vitro, with custom inverse methods to infer the best-fit material parameters and the rupture stresses and strains. Similar approaches have also applied to characterize the material parameters of soft tissues in vivo, where advanced medical imaging can provide precise measurements of tissue deformation under different modes of action, and inverse methodologies are used to derive material properties from measured data. Nowadays, these approaches offer important possibilities for fundamental mechanobiology which aims at gaining better insight in the growth, remodeling and ageing effects in biological tissues. It is well-known that biological soft tissues appear to develop, grow, remodel, and adapt so as to maintain particular mechanical metrics (e.g., stress) near target values. To accomplish this, tissues often develop regionally varying stiffness, strength and anisotropy. Important challenges in soft tissue mechanics are now to develop and implement hybrid experimental - computational method to quantify regional variations in properties in situ.
The main motivation of the symposium is to review the latest progress and permit scientific discussions on these methods by bringing together researchers interested by characterizing material properties of soft tissues. Topics to be considered are related to the different challenges posed by inverse problems in soft tissue biomechanics and mechanobiology, such as: - optimization approaches and model order reduction - model fitting against uncertain experimental results - uniqueness of identified parameters - reliability of computational models for biological tissues - uncertainty assessment in inverse problems - optical full-field strain measurements - digital image/volume correlation - in vivo identification using medical imaging - virtual fields method - regularization approaches - inverse deformation problem - machine-learning and other data-driven approaches for parameter identification - hyperelastic image registration
#5: Mini Symposium: Imaging Based Computational Modeling in Orthopedic Biomechanics and Mechanobiology
Co-Chairs: Professor Abdelwahed BARKAOUI, International University of Rabat, Morocco
Professor João manuel R. S. TAVARES, University of Porto, Portugal
Professor Patrick CHABRAND, Aix-Marseille University, France
Summary: In the field of orthopedic biomechanics, the geometry, the constituent’s elements of the joints and material properties of tissues are the most important parameters for the study of biomechanical and mechanobiology behavior of bone tissue as well as the diagnosis and choice of treatment. Medical imaging is a useful tool which has revolutionized the understanding and diagnostics in the fields of biomechanics and mechanobiology. Recently, the development and improvement of software and hardware for medical imaging has progressed enormously so that new technics have been discovered and developed. Medical imaging is now widely used for bone alignment measurements, joint motion studies, stress and strain analysis, and to determine the material properties of the musculoskeletal system and of construction. Moreover, some imaging techniques allow the generation of three-dimensional specific patient models used for finite elements (FEs) based studies. In the recent decades, FE methods have been widely used in the field of biomechanics engineering and in the regenerative medicine. Human bone FE modeling have provided a potential tool in assessing a wide variety of outcomes in a parametric and repeatable manner. These models are commonly derived from medical images using different imaging algorithms and tools. This mini-symposium will be a forum focus on presenting and discussing recent approaches combining FE methods and pacific subject modelling based on medical imaging techniques, mainly addressing orthopedic biomechanics and mechanobiology studies.
Keywords: Bone biomechanics, Mechanobiology, Biomedical imaging, Computational modeling, Finite Element Methods
#6: Mini Symposium: Implanted Medical Devices Design and Advanced Manufacturing for Biomedical Engineering
Co-Chairs: ProfessorLizhen Wang, Beihang University, China
Dr. Qiang Chen, Southeast University, China
Summary: It is well known that implanted medical devices are used at a rapid pace to repair or replace human tissues or organs for enhancing their functions such as artificial joints, dental implants, vascular stents, etc. Moreover, under the advanced manufacturing technology (3D Bioprinting), personal customized implants, which can meet the specific needs of each patient, have become an overwhelming trend since the production of advanced manufacturing is fast and the cost of customization can also be reduced. However, there are still great challenges in the implants application, restenosis after vascular implantation, the change of biomaterial properties and structure of scaffold itself after a long-term of interaction with blood or tissue, control strategy of biomaterial degradation rate, complex biomechanical problems etc. The purpose of this symposium forum is to call experts together for exchanging the ideas about how to tackle with current problems.
Topics will include but not be limited to:
1. The biomechanical mechanism of the interaction between implanted medical devices and tissue. 2. Biomechanical modeling and computational simulation technology of implanted medical devices. 3. Optimization technology of implant material configuration design 4. 3D printing technology in orthopaedic and cardiovascular implant application 5. 3D bioprinting implant for inducing tissue regeneration
Keywords: Implanted Medical Devices, Advanced Manufacturing, Biomechanics, Biomaterials, 3D printing